Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans.

ABSTRACT: Nitrated fatty acids are endogenously present in human and animal tissues, as well as in plant-derived oils. In particular, 10-nitro oleic acid (10-NO₂-OA) potently induces Nrf2-dependent antioxidant gene expression and inhibits TLR4/NF-κB signaling, thus promoting an overall cyto-protective and anti-inflammatory response. 10-NO₂-OA has been extensively tested in animal models and is currently undergoing clinical evaluation in humans. Bio-elimination pathways for 10-NO₂-OA were evaluated in rats (30 mg/kg·day) and in humans (0.34 mg/kg) using samples obtained from a double-blind, dose-rising clinical trial. Quantitative radiochromatographic/MS analysis indicated that the renal and fecal pathways are the main routes for 10-NO₂-OA excretion in rats

SUBMITTER: Salvatore SR 

PROVIDER: S-EPMC5215368 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature