Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.

ABSTRACT:

Background & aims

The occurrence of drug-induced liver injury (DILI) is a major issue in all phases of drug development. To identify novel biomarker candidates associated with DILI, we utilised an affinity proteomics strategy, where antibody suspension bead arrays were applied to profile plasma and serum samples from human DILI cases and controls.

Methods

An initial screening was performed using 4594 randomly selected antibodies, representing 3450 human proteins. Resulting candidate proteins together with proposed DILI biomarker candidates generated a DILI array of 251 proteins for subsequent target analysis and verifications. In total, 1196 samples from 241 individuals across four independent cohorts were profiled: healthy volunteers receiving acetaminophen, patients with h

SUBMITTER: Mikus M 

PROVIDER: S-EPMC5215406 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature