Dispersion of Nanoparticles in Different Media Importantly Determines the Composition of Their Protein Corona.

ABSTRACT: Protein corona of nanoparticles (NPs), which forms when these particles come in to contact with protein-containing fluids, is considered as an overlooked factor in nanomedicine. Through numerous studies it has been becoming increasingly evident that it importantly dictates the interaction of NPs with their surroundings. Several factors that determine the compositions of NPs protein corona have been identified in recent years, but one has remained largely ignored-the composition of media used for dispersion of NPs. Here, we determined the effect of dispersion media on the composition of protein corona of polyacrylic acid-coated cobalt ferrite NPs (PAA NPs) and silica NPs. Our results confirmed some of the basic premises such as NPs type-dependent specificity of the protein corona. But more

SUBMITTER: Strojan K 

PROVIDER: S-EPMC5215476 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature