Altered cortical beta-band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis.

ABSTRACT: Continuous rhythmic neuronal oscillations underpin local and regional cortical communication. The impact of the motor system neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) on the neuronal oscillations subserving movement might therefore serve as a sensitive marker of disease activity. Movement preparation and execution are consistently associated with modulations to neuronal oscillation beta (15-30 Hz) power. Cortical beta-band oscillations were measured using magnetoencephalography (MEG) during preparation for, execution, and completion of a visually cued, lateralized motor task that included movement inhibition trials. Eleven "classical" ALS patients, 9 with the primary lateral sclerosis (PLS) phenotype, and 12 asymptomatic carriers of ALS-associated gene mutations were c

SUBMITTER: Proudfoot M 

PROVIDER: S-EPMC5215611 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature