Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice.

ABSTRACT: MYH14 is a member of the myosin family, which has been implicated in many motile processes such as ion-channel gating, organelle translocation, and the cytoskeleton rearrangement. Mutations in MYH14 lead to a DFNA4-type hearing impairment. Further evidence also shows that MYH14 is a candidate noise-induced hearing loss (NIHL) susceptible gene. However, the specific roles of MYH14 in auditory function and NIHL are not fully understood. In the present study, we used CRISPR/Cas9 technology to establish a Myh14 knockout mice line in CBA/CaJ background (now referred to as Myh14^-/- mice) and clarify the role of MYH14 in the cochlea and NIHL. We found that Myh14^-/- mice did not exhibit significant hearing loss until five months of age. In addition, Myh14^-/- mice w

SUBMITTER: Fu X 

PROVIDER: S-EPMC5215640 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature