Crohn's Disease Localization Displays Different Predisposing Genetic Variants.

ABSTRACT:

Background

Crohn's disease (CD) is a pathologic condition with different clinical expressions that may reflect an interplay between genetics and environmental factors. Recently, it has been highlighted that three genetic markers, NOD2, MHC and MST1, were associated to distinct CD sites, supporting the concept that genetic variations may contribute to localize CD. Genetic markers, previously shown to be associated with inflammatory bowel disease (IBD), were tested in CD patients with the aim to better dissect the genetic relationship between ileal, ileocolonic and colonic CD and ascertain whether a different genetic background would support the three disease sites as independent entities.

Methods

A panel of 29 SNPs of 19 IBD loci were analyzed by TaqMan SNP allelic discrimina

SUBMITTER: Palmieri O 

PROVIDER: S-EPMC5215692 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature