Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review.

ABSTRACT:

Objective

To evaluate the effects of angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists (AIIRAs) on renal outcomes and all cause mortality in patients with diabetic nephropathy.

Data sources

Medline, Embase, the Cochrane controlled trials register, conference proceedings, and contact with investigators.

Study selection

Trials comparing ACE inhibitors or AIIRAs with placebo or with each other in patients with diabetic nephropathy.

Data extraction

Mortality, renal outcomes (end stage renal disease, doubling of serum creatinine concentration, prevention of progression of microalbuminuria to macroalbuminuria, remission of microalbuminuria), and quality of trials.

Data synthesis

36 of 43 identified trials compared ACE inhib

SUBMITTER: Strippoli GF 

PROVIDER: S-EPMC521570 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature