Neurocognitive functioning and genetic variation in patients with primary brain tumours.

ABSTRACT: Impairment of neurocognitive functioning is a common result of cerebral neoplasms and treatment, although there is substantial heterogeneity in the pattern and severity of neurocognitive dysfunction across individuals and tumour types. The effects of many clinical and patient characteristics on neurocognitive functioning have been documented, but little research has been devoted to understanding the effect of genetic variation on neurocognitive outcomes in patients with brain tumours. This Review highlights preliminary evidence that suggests an association between various genes and risk of adverse neurocognitive outcomes in patients with brain tumours. Studies include genes specific to neuronal function, and those associated with more systemic cellular regulation. Related scientific litera

SUBMITTER: Wefel JS 

PROVIDER: S-EPMC5215729 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature