Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic Inflammation.

ABSTRACT:

Rationale

Epidemiological evidence indicates that exposures to fine particulate matter air pollution (PM_2.5) contribute to global burden of disease, primarily as a result of increased risk of cardiovascular morbidity and mortality. However, mechanisms by which PM_2.5 exposure induces cardiovascular injury remain unclear. PM_2.5-induced endothelial dysfunction and systemic inflammation have been implicated, but direct evidence is lacking.

Objective

To examine whether acute exposure to PM_2.5 is associated with endothelial injury and systemic inflammation.

Methods and results

Blood was collected from healthy, nonsmoking, young adults during 3 study periods that included episodes of elevated PM_2.5 levels. Microparticles

SUBMITTER: Pope CA 

PROVIDER: S-EPMC5215745 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature