Ontology highlight
ABSTRACT:
SUBMITTER: Zacher B
PROVIDER: S-EPMC5215863 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Zacher Benedikt B Michel Margaux M Schwalb Björn B Cramer Patrick P Tresch Achim A Gagneur Julien J
PloS one 20170105 1
Accurate maps of promoters and enhancers are required for understanding transcriptional regulation. Promoters and enhancers are usually mapped by integration of chromatin assays charting histone modifications, DNA accessibility, and transcription factor binding. However, current algorithms are limited by unrealistic data distribution assumptions. Here we propose GenoSTAN (Genomic STate ANnotation), a hidden Markov model overcoming these limitations. We map promoters and enhancers for 127 cell ty ...[more]