Subacute Subclinical Brain Infarctions after Transcatheter Aortic Valve Implantation Negatively Impact Cognitive Function in Long-Term Follow-Up.

ABSTRACT:

Aims

To date every post-procedural cerebrovascular embolic event (CVE) is dreaded for its potential to accelerate cognitive decline after transcatheter aortic valve implantation (TAVI). This study differentiates the impact of acute (procedural) and post-acute cerebrovascular embolic events (CVEs) on cognitive performance.

Methods

Magnetic resonance imaging (MRI) before, early and late after TAVI was performed to quantify embolic burden. Quantification of diffusion- and T1-weighted lesions, as well as white-matter and total brain volumes, as well as cognitive function testing (MMSE) were assessed in 28 patients with a medium follow-up period of 34 months.

Results

Procedural diffusion-weighted lesions were observed in 17 patients (61%), but demonstrated locoregional rem

SUBMITTER: Ghanem A 

PROVIDER: S-EPMC5215955 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature