Poor Prognosis After Second Locoregional Recurrences in the CALOR Trial.

ABSTRACT:

Background

Isolated locoregional recurrences (ILRRs) of breast cancer confer a significant risk for the development of distant metastasis. Management practices and second ILRR events in the Chemotherapy as Adjuvant for LOcally Recurrent breast cancer (CALOR) trial were investigated.

Methods

In this study, 162 patients with ILRR were randomly assigned to receive postoperative chemotherapy or no chemotherapy. Descriptive statistics characterize outcomes according to local therapy and the influence of hormone receptor status on subsequent recurrences. Competing risk regression models, Kaplan-Meier estimates, and Cox proportional hazards models were used to evaluate associations between treatment, site of second recurrence, and outcome.

Results

The median follow-up period

SUBMITTER: Wapnir IL 

PROVIDER: S-EPMC5215961 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature