Current Pharmacological Approaches to Reduce Chorea in Huntington's Disease.

ABSTRACT: There are currently no effective pharmacological agents available to stop or prevent the progression of Huntington's disease (HD), a rare hereditary neurodegenerative disorder. In addition to psychiatric symptoms and cognitive impairments, HD causes progressive motor disturbances, in particular choreiform movements, which are characterized by unwanted contractions of the facial muscles, trunk and extremities. Management of choreiform movements is usually advised if chorea interferes with daily functioning, causes social isolation, gait instability, falls, or physical injury. Although drugs to reduce chorea are available, only few randomized controlled studies have assessed the efficacy of these drugs, resulting in a high variety of prescribed drugs in clinical practice. The current pharmac

SUBMITTER: Coppen EM 

PROVIDER: S-EPMC5216093 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature