Persistence of atopic dermatitis (AD): A systematic review and meta-analysis.

ABSTRACT:

Background

Previous studies found conflicting results about whether childhood atopic dermatitis (AD) persists into adulthood.

Objective

We sought to determine persistence rates and clinical factors associated with prolonged AD.

Methods

A systematic review was performed in MEDLINE, EMBASE, Scopus, GREAT, LILACS, Web of Science, Academic Search Complete, and Cochrane Library. Meta-analysis was performed using Kaplan-Meier plots and random-effects proportional hazards regression.

Results

In total, 45 studies including 110,651 subjects spanning 434,992 patient-years from 15 countries were included. In pooled analysis, 80% of childhood AD did not persist by 8 years and less than 5% persisted by 20 years after diagnosis (mean ± SE: 6.1 ± 0.02 years). Children with AD

SUBMITTER: Kim JP 

PROVIDER: S-EPMC5216177 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature