KCNQ1 rs2237895 polymorphism is associated with Gestational Diabetes in Pakistani Women.

ABSTRACT:

Background and objective

Genetic studies on gestational diabetes (GDM) are relatively scarce; moreover, limited data is available for KCNQ1 polymorphism in Pakistani pregnant women. We aimed to determine the frequency of KCNQ1 rs2237895 in GDM and normal pregnant controls and its association with GDM-related phenotypes.

Methods

A total of 637 pregnant females (429 controls and 208 cases) in their second trimester were classified according to the International Association of the Diabetes and Pregnancy Study criteria in this study. Their blood samples were genotyped for KCNQ1 SNP rs2237895 using PCR-RFLP method and sequencing. Fasting and two hour-post glucose load blood levels, serum HbA1c, insulin, and anthropometric assessment was performed.: Pearson's Chi Square test, Mann

SUBMITTER: Fatima SS 

PROVIDER: S-EPMC5216286 | biostudies-literature | 2016 Nov-Dec

REPOSITORIES: biostudies-literature