Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics.

ABSTRACT: Optogenetics, a widely used technique in neuroscience research, is often limited by its invasive nature of application. Here, we present a noninvasive, ultrasound-based technique to introduce optogenetic channels into the brain by temporarily opening the blood-brain barrier (BBB). We demonstrate the efficiency of the method developed and evaluate the bioactivity of the non-invasively introduced channelrhodopsin channels by performing stimulation in freely behaving mice.

SUBMITTER: Wang S 

PROVIDER: S-EPMC5216389 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature