Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.

ABSTRACT: Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

SUBMITTER: Luo X 

PROVIDER: S-EPMC5216453 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature