A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.

ABSTRACT:

Background

Long-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation.

Methods

We originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo₂], 89 to 93%). After 7 months and the randomization of 34 patients, the trial was redesigned to also include patients who had stable COPD with moderate exercise-induced desaturation (during the 6-minute walk test, Spo₂ ≥80% for ≥5 minutes and <90% for ≥10

SUBMITTER: Long-Term Oxygen Treatment Trial Research Group 

PROVIDER: S-EPMC5216457 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature