Immune adaptation to chronic intense exercise training: new microarray evidence.

ABSTRACT:

Background

Endurance exercise training, especially the high-intensity training, exhibits a strong influence on the immune system. However, the mechanisms underpinning the immune-regulatory effect of exercise remain unclear. Consequently, we chose to investigate the alterations in the transcriptional profile of blood leukocytes in young endurance athletes as compared with healthy sedentary controls, using Affymetrix human gene 1.1 ST array.

Results

Group differences in the transcriptome were analyzed using Intensity-based Hierarchical Bayes method followed by a Logistic Regression-based gene set enrichment method. We identified 72 significant transcripts differentially expressed in the leukocyte transcriptome of young endurance athletes as compared with non-athlete controls w

SUBMITTER: Liu D 

PROVIDER: S-EPMC5216585 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature