Sunitinib-induced morpho-functional changes and drug effectiveness in malignant solitary fibrous tumours.

ABSTRACT: Sunitinib improves the outcomes of patients with solitary fibrous tumours (SFTs). The aim of this study was to investigate and contextualise sunitinib-induced morpho-functional changes in order to gain insights into the drug's mechanism of action.To this end, four surgical specimens obtained from two sunitinib-responsive patients with malignant SFT, and one primary cell culture obtained from fresh tumoral tissue and its stabilised cell line, were studied by means of immunohistochemistry, bright field in situ hybridisation, immunofluorescence/confocal microscopy, and biochemistry.The post-sunitinib surgical samples were characterised by two biologically relevant morpho-functional changes: clear areas and necrotic foci. The first were associated with the attenuation/loss of PDGFRB expression

SUBMITTER: Spagnuolo RD 

PROVIDER: S-EPMC5216702 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature