Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma.

ABSTRACT: Long non-coding RNAs (lncRNAs) modulate gene expression, and lncRNA misregulation is associated with cancer. However, precise functional roles in biological and disease processes have been described for only a few lncRNAs. Identification of genome-wide lncRNA-mediated transcriptional dysregulations may improve cancer treatments. In the present study, we used a computational framework that combined lncRNA and gene expression profiles with transcription factor (TF)-target relationships to comprehensively identify dysregulatory lncRNA-TF-gene triplets. In glioblastoma (GBM), we found that most lncRNAs affect multiple targets and primarily affect TF activity in trans. Six different classes of lncRNA-mediated transcriptional dysregulations were identified, with most lncRNAs either enhancing or

SUBMITTER: Li Y 

PROVIDER: S-EPMC5216703 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature