Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.

ABSTRACT: Development of colorectal cancer (CRC) involves sequential transformation of normal mucosal tissues into benign adenomas and then adenomas into malignant tumors. The identification of genes crucial for malignant transformation in colorectal adenomas (CRAs) has been based primarily on cross-sectional observations. In this study, we identified relevant genes using autologous samples. By performing genome-wide SNP genotyping and RNA sequencing analysis of adenocarcinomas, adenomatous polyps, and non-neoplastic colon tissues (referred as tri-part samples) from individual patients, we identified 68 genes with differential copy number alterations and progressively dysregulated expression. Aurora A, SKA3, and DSN1 protein levels were sequentially up-regulated in the samples, and this overexpressi

SUBMITTER: Chuang TP 

PROVIDER: S-EPMC5216762 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature