Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer.

ABSTRACT: Colorectal cancer remains a major public health problem worldwide. Despite the introduction of antiangiogenic drugs for the treatment of metastatic disease, a large number of issues remains unresolved. In particular, studies on predictive biomarkers of response and pathways of resistance to these agents are lacking, making it difficult to accurately select candidates for treatment. Hypoxia is the prime driving force for tumor angiogenesis and a vicious cycle between hypoxia and angiogenesis can be observed in tumors. Anti-angiogenic drugs act inhibiting tumor vasculature and, as consequence, inducing hypoxia. However, hypoxia could, in turn, induce an increase of metastatic potential of cells and a series of phenomena that could induce drug resistance. In the present review biological mech

SUBMITTER: Ulivi P 

PROVIDER: S-EPMC5216829 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature