CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility.

ABSTRACT: Colorectal cancer (CRC) is the third most common cancer. Large-scale genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants in European ancestry including the CDH1 rs9929218. Following GWAS and candidate studies evaluated the association between the CDH1 rs9929218 polymorphism and CRC in European, Asian and American populations. However, these studies reported inconsistent associations. Evidence shows that rs9929218 may regulate different gene expressions in different human tissues. Here, we reevaluated this association using large-scale samples from 16 studies (n=131768) using a meta-analysis method. In heterogeneity test, we did not identify significant heterogeneity among these studies. Meta-analysis using fixed effect model showed

SUBMITTER: Han P 

PROVIDER: S-EPMC5216941 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature