The effect of oxythioquinox exposure on normal human mammary epithelial cell gene expression: a microarray analysis study.

ABSTRACT:

Background

Inter-individual variation in normal human mammary epithelial cells in response to oxythioquinox (OTQ) is reported. Gene expression signatures resulting from chemical exposures are generally created from analysis of exposures in rat, mouse or other genetically similar animal models, limiting information about inter-individual variations. This study focused on the effect of inter-individual variation in gene expression signatures.

Methods

Gene expression was studied in primary normal human mammary epithelial cells (NHMECs) derived from four women undergoing reduction mammoplasty [Cooperative Human Tissue Network (National Cancer Institute and National Disease Research Interchange)]. Gene transcription in each cell strain was analyzed using high-density oligonucleot

SUBMITTER: Gwinn MR 

PROVIDER: S-EPMC521696 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature