Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation.

ABSTRACT: Cyclin D1 is a cell cycle protein that promotes proliferation by mediating progression through key checkpoints in G1 phase. It is also a proto-oncogene that is commonly overexpressed in human cancers. In addition to its canonical role in controlling cell cycle progression, cyclin D1 affects other aspects of cell physiology, in part through transcriptional regulation. In this study, we find that cyclin D1 inhibits the activity of a key metabolic transcription factor, peroxisome proliferator-activated receptor α (PPARα), a member of nuclear receptor family that induces fatty acid oxidation and may play an anti-neoplastic role. In primary hepatocytes, cyclin D1 inhibits PPARα transcriptional activity and target gene expression in a cdk4-independent manner. In liver and breast cancer cells, kn

SUBMITTER: Kamarajugadda S 

PROVIDER: S-EPMC5216970 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature