Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agents.

ABSTRACT: Despite advances in the development of clinical agents for treating Mantle Cell Lymphoma (MCL), treatment of MCL remains a challenge due to complexity and frequent relapse associated with MCL. The incorporation of conventional and novel diagnostic approaches such as genomic sequencing have helped improve understanding of the pathogenesis of MCL, and have led to development of specific agents targeting signaling pathways that have recently been shown to be involved in MCL. In this review, we first provide a general overview of MCL and then discuss about the role of biomarkers in the pathogenesis, diagnosis, prognosis, and treatment for MCL. We attempt to discuss major biomarkers for MCL and highlight published and ongoing clinical trials in an effort to evaluate the dominant signaling pathw

SUBMITTER: Inamdar AA 

PROVIDER: S-EPMC5217048 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature