Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging.

ABSTRACT: Sleep-disordered breathing produces cognitive impairments, and is possibly associated with Alzheimer disease (AD). Intermittent hypoxia treatment (IHT), an experimental model for sleep-disordered breathing, results in cognitive impairments in animals via unknown mechanisms. Here, we exposed mice to IHT protocols, and performed biochemical analyses and microarray analyses regarding their hippocampal samples. In particular, we performed gene ontology (GO)-based microarray analysis to elucidate effects of IHT on hippocampal functioning, which were compared with the effects of various previously-reported experimental conditions on that (ref. Gene Expression Omnibus, The National Center for Biotechnology Information). Our microarray analyses revealed that IHT and aging shared alterations in som

SUBMITTER: Yagishita S 

PROVIDER: S-EPMC5217192 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature