Meta-analysis reveals conserved cell cycle transcriptional network across multiple human cell types.

ABSTRACT:

Background

Cell division is central to the physiology and pathology of all eukaryotic organisms. The molecular machinery underpinning the cell cycle has been studied extensively in a number of species and core aspects of it have been found to be highly conserved. Similarly, the transcriptional changes associated with this pathway have been studied in different organisms and different cell types. In each case hundreds of genes have been reported to be regulated, however there seems to be little consensus in the genes identified across different studies. In a recent comparison of transcriptomic studies of the cell cycle in different human cell types, only 96 cell cycle genes were reported to be the same across all studies examined.

Results

Here we perform a systematic re-exami

SUBMITTER: Giotti B 

PROVIDER: S-EPMC5217208 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature