Potential unfavorable impacts of BDNF Val66Met polymorphisms on metabolic risks in average population in a longevous area.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) has been implicated in cognitive performance and the modulation of several metabolic parameters in some disease models, but its potential roles in successful aging remain unclear. We herein sought to define the putative correlation between BDNF Val66Met and several metabolic risk factors including BMI, blood pressure, fasting plasma glucose (FPG) and lipid levels in a long-lived population inhabiting Hongshui River Basin in Guangxi.

Methods

BDNF Val66Met was typed by ARMS-PCR for 487 Zhuang long-lived individuals (age ≥ 90, long-lived group, LG), 593 of their offspring (age 60-77, offspring group, OG) and 582 ethnic-matched healthy controls (aged 60-75, control group, CG) from Hongshui River Basin. The correlations of genot

SUBMITTER: Peng JH 

PROVIDER: S-EPMC5217242 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature