LPS-induced modules of co-expressed genes in equine peripheral blood mononuclear cells.

ABSTRACT:

Background

Lipopolysaccharide (endotoxin, LPS) is a strong inducer of the innate immune response. It is widespread in our environment, e.g. in house dust and contributes to asthma. Compared to humans, horses are even more sensitive to LPS. However, data on LPS effects on the equine transcriptome are very limited. Using RNA-seq we analysed LPS-induced differences in the gene expression in equine peripheral blood mononuclear cells at the gene and gene-network level in two half-sib families and one group of unrelated horses.

Results

24 h-LPS challenge of equine immune cells resulted in substantial changes in the transcriptomic profile (1,265 differentially expressed genes) showing partial overlap with human data. One of the half-sib families showed a specific response different

SUBMITTER: Pacholewska A 

PROVIDER: S-EPMC5217269 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature