Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies.

ABSTRACT:

Background

Primary cardiac angiosarcomas are rare, but they are the most aggressive type of primary cardiac neoplasms. When patients do present, it is with advanced pulmonary and/or cardiac symptoms. Therefore, many times the correct diagnosis is not made at the time of initial presentation. These patients have metastatic disease and the vast majority of these patients die within a few months after diagnosis. Currently the treatment choices are limited and there are no targeted therapies available.

Case presentation

A 56-year-old male presented with shortness of breath, night sweats, and productive cough for a month. Workup revealed pericardial effusion and multiple bilateral pulmonary nodules suspicious for metastatic disease. Transthoracic echocardiogram showed a large per

SUBMITTER: Zhrebker L 

PROVIDER: S-EPMC5217318 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature