Distinct membrane properties are differentially influenced by cardiolipin content and acyl chain composition in biomimetic membranes.

ABSTRACT: Cardiolipin (CL) has a critical role in maintaining mitochondrial inner membrane structure. In several conditions such as heart failure and aging, there is loss of CL content and remodeling of CL acyl chains, which are hypothesized to impair mitochondrial inner membrane biophysical organization. Therefore, this study discriminated how CL content and acyl chain composition influenced select properties of simple and complex mitochondrial mimicking model membranes. We focused on monolayer excess area/molecule (a measure of lipid miscibility), bilayer phase transitions, and microdomain organization. In monolayer compression studies, loss of tetralinoleoyl [(18:2)₄] CL content decreased the excess area/molecule. Replacement of (18:2)₄CL acyl chains with tetraoleoyl [(18:1)

SUBMITTER: Pennington ER 

PROVIDER: S-EPMC5217480 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature