Gastroesophageal junction adenocarcinoma displays abnormalities in homologous recombination and nucleotide excision repair.

ABSTRACT:

Objective

Esophageal adenocarcinoma (EAC) continues to be a disease associated with high mortality. Among the factors leading to poor outcomes are innate resistance to currently available therapies, advanced stage at diagnosis, and complex biology. Platinum and ionizing radiation form the backbone of treatment for the majority of patients with EAC. Of the multiple processes involved in response to platinum chemotherapy or ionizing radiation, deoxyribonucleic acid (DNA) repair has been a major player in cancer sensitivity to these agents. DNA repair defects have been described in various malignancies. The purpose of this study was to determine whether alterations in DNA repair are present in EAC compared with normal gastroesophageal tissues.

Methods

We analyzed the expression

SUBMITTER: Dewalt RI 

PROVIDER: S-EPMC5217507 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature