Growth, progression and chromosome instability of Neuroblastoma: a new scenario of tumorigenesis?

ABSTRACT:

Background

Neuroblastoma is a pediatric cancer with a low survival rate of patients with metastatic stage 4 disease. Tumor aggressiveness and progression have been associated with structural copy number variations (CNVs) that are observed in malignant cells. In contrast, localized Neuroblastomas, which are associated with a low number of structural CNVs but frequent numerical CNVs, are less aggressive, and patients have good outcomes. Finally, whole-genome and whole-exome sequencing of Neuroblastoma tissues have shown few damaging mutations in these tumors.

Conclusions

In the present report it is proposed that chromosome instability (CIN) plays a major role in Neuroblastoma tumorigenesis and that CIN is already present in the early phases of tumor development. High CIN can p

SUBMITTER: Tonini GP 

PROVIDER: S-EPMC5217541 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature