Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups.

ABSTRACT:

Background

Little is known about the association of the single nucleotide polymorphism (SNP) of rs364585 near serine palmitoyl-transferase long-chain base subunit 3 gene (SPTLC3) and serum lipid profiles. The present study was detected the association of the SPTLC3 rs364585 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations.

Methods

Genotyping of the SPTLC3 rs364585 SNP was performed in 824 unrelated individuals of Han and 783 participants of Jing by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.

Results

There was no significant difference in either genotypic or allelic frequencies between Han and Jing, or between males and f

SUBMITTER: Zhang QH 

PROVIDER: S-EPMC5217591 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature