Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study.

ABSTRACT:

Background

The causes of autism likely involve genetic and environmental factors that influence neurobiological changes and the neurological and behavioral features of the disorder. Immune factors and inflammation are hypothesized pathogenic influences, but have not been examined longitudinally.

Methods

In a cohort of 104 participants with autism, we performed an assessment of immune mediators such as cytokines, chemokines, or growth factors in serum and cerebrospinal fluid (n = 67) to determine potential influences of such mediators in autism.

Results

As compared with 54 typically developing controls, we found no evidence of differences in the blood profile of immune mediators supportive of active systemic inflammation mechanisms in participants with autism. S

SUBMITTER: Pardo CA 

PROVIDER: S-EPMC5217649 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature