Brain State Dependence of Hippocampal Subthreshold Activity in Awake Mice.

ABSTRACT: Monitoring the membrane potential of individual neurons has uncovered how single-cell properties contribute to network processing across different brain states in neocortex. In contrast, the subthreshold modulation of hippocampal neurons by brain state has not been systematically characterized. To address this, we combined whole-cell recordings from dentate granule cells and CA1 pyramidal neurons with multisite extracellular recordings and behavioral measurements in awake mice. We show that the average membrane potential, amplitude of subthreshold fluctuations, and distance to spike threshold are all modulated by brain state. Furthermore, even within individual states, rapid variations in arousal are reflected in membrane potential fluctuations. These factors produce depolarizing ramps in

SUBMITTER: Hulse BK 

PROVIDER: S-EPMC5217705 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature