Human Spermatozoa Quantitative Proteomic Signature Classifies Normo- and Asthenozoospermia.

ABSTRACT: Scarcely understood defects lead to asthenozoospermia, which results in poor fertility outcomes. Incomplete knowledge of these defects hinders the development of new therapies and reliance on interventional therapies, such as in vitro fertilization, increases. Sperm cells, being transcriptionally and translationally silent, necessitate the proteomic approach to study the sperm function. We have performed a differential proteomics analysis of human sperm and seminal plasma and identified and quantified 667 proteins in sperm and 429 proteins in seminal plasma data set, which were used for further analysis. Statistical and mathematical analysis combined with pathway analysis and self-organizing maps clustering and correlation was performed on the data set.It was found that sperm proteomic sig

SUBMITTER: Saraswat M 

PROVIDER: S-EPMC5217782 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature