Piceatannol exhibits anti-inflammatory effects on macrophages interacting with adipocytes.

ABSTRACT: Piceatannol (PIC), a natural analog of resveratrol (RES), is a phytochemical found in passion fruit seeds. To clarify the effects of PIC on obesity-induced inflammation in adipose tissue, we investigated the anti-inflammatory activity of PIC-related compounds (PIC, RES, and metabolites from PIC) in culture models of obese adipose tissue. Lipopolysaccharide (LPS) and conditioned medium from 3T3-L1 adipocytes (3T3-L1-CM) enhanced proinflammatory gene expression and synthesis of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in RAW264.7 macrophages. Although each compound inhibited the mRNA expression of iNOS (inducible NO synthase), TNF-α, and IL-6, PIC potently inhibited them, and 30 μmol/L PIC suppressed the LPS- and 3T3-L1-CM-induc

SUBMITTER: Yamamoto T 

PROVIDER: S-EPMC5217925 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature