Mild hyperglycemia triggered islet function recovery in streptozotocin-induced insulin-deficient diabetic rats.

ABSTRACT:

Aims/introduction

Moderate elevation of glucose level has been shown to effectively promote β-cell replication in various models in vitro and in normal rodents. Here, we aimed to test the effect of moderately elevated glucose on β-cell mass expansion and islet function recovery in diabetic animal models.

Materials and methods

A single high dose of streptozotocin was given to induce insulin-deficient diabetes in adult male Sprague-Dawley rats. Then, 48 h after streptozotocin injection, newly diabetic rats were randomly divided into three groups: (i) no treatment to maintain hyperglycemia; (ii) daily exogenous long-acting human insulin analog injection that maintained mild hyperglycemia (15 mmol/L < blood glucose < 18 mmol/L); (iii) daily exogenous long-acting human insulin an

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC5217940 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature