HIV Infects Bronchial Epithelium and Suppresses Components of the Mucociliary Clearance Apparatus.

ABSTRACT: Recurrent lung infections and pneumonia are emerging as significant comorbidities in the HIV-infected population in the era of combination antiretroviral therapy (cART). HIV infection has been reported to suppress nasal mucociliary clearance (MCC). Since the primary components driving nasal MCC and bronchial MCC are identical, it is possible that bronchial MCC is affected as well. Effective MCC requires optimal ciliary beating which depends on the maintenance of the airway surface liquid (ASL), a function of cystic fibrosis transmembrane conductance regulator (CFTR) activity and the integrity of the signaling mechanism that regulates ciliary beating and fluid secretion. Impairment of either component of the MCC apparatus can compromise its efficacy and promote microbial colonization. We de

SUBMITTER: Chinnapaiyan S 

PROVIDER: S-EPMC5217953 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature