The Association between GABA-Modulators and Clostridium difficile Infection - A Matched Retrospective Case-Control Study.

ABSTRACT:

Objective

Recently, metabolomics studies have suggested that the neurotransmitter γ-amino butyric acid (GABA) may modulate C. difficile infection (CDI) pathogenesis. In the present study, we investigated the association between GABA-modulating pharmaceuticals and CDI development.

Methods

In July-December 2013, we performed a matched, retrospective case-control study in Skåne county, Sweden, to assess the association between the use of GABA-modulators (defined as regular use of at least one of the following: zolpidem, zopiclone, benzodiazepines, gabapentin, pregabalin or baclofen) and CDI. Multivariate regression models, adjusted for known risk factors for CDI, were fitted to assess the associations and a propensity score-adjusted analysis was performed.

Results

The st

SUBMITTER: Strom J 

PROVIDER: S-EPMC5217962 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature