Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease.

ABSTRACT:

Background

Thiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD).

Objective

To clarify the mechanism for the reduction of thiamine diphosphate (TDP), an active form of thiamine and critical coenzyme of glucose metabolism, in AD.

Methods

Forty-five AD patients clinically diagnosed and 38 age- and gender-matched control subjects without dementia were voluntarily recruited. The contents of blood TDP, thiamine monophosphate (TMP), and thiamine, as well as the activities of thiamine diphosphatase (TDPase), thiamine monophosphatase (TMPase), and thiamine pyrophosphokinase (TPK), were assayed by high performance liquid chromatography.

Results

Blood TDP contents of AD patients were significantly lower than those in c

SUBMITTER: Pan X 

PROVIDER: S-EPMC5218390 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature