Computed Tomographic Distinction of Intimal and Medial Calcification in the Intracranial Internal Carotid Artery.

ABSTRACT:

Background

Intracranial internal carotid artery (iICA) calcification is associated with stroke and is often seen as a proxy of atherosclerosis of the intima. However, it was recently shown that these calcifications are predominantly located in the tunica media and internal elastic lamina (medial calcification). Intimal and medial calcifications are thought to have a different pathogenesis and clinical consequences and can only be distinguished through ex vivo histological analysis. Therefore, our aim was to develop CT scoring method to distinguish intimal and medial iICA calcification in vivo.

Methods

First, in both iICAs of 16 cerebral autopsy patients the intimal and/or medial calcification area was histologically assessed (142 slides). Brain CT images of these patients we

SUBMITTER: Kockelkoren R 

PROVIDER: S-EPMC5218397 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature