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AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins.

ABSTRACT: Cloning, sequencing, and biochemical analysis identified a novel AmpC-type beta-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephalosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly.

SUBMITTER: Mammeri H 

PROVIDER: S-EPMC521871 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature

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AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins.

Mammeri Hedi H   Nazic Hasan H   Naas Thierry T   Poirel Laurent L   Léotard Sophie S   Nordmann Patrice P  

Antimicrobial agents and chemotherapy 20041001 10

Cloning, sequencing, and biochemical analysis identified a novel AmpC-type beta-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephalosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly. ...[more]

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