Absorbed radiation dosimetry of the D₃-specific PET radioligand [¹⁸F]FluorTriopride estimated using rodent and nonhuman primate.

ABSTRACT: [¹⁸F]FluorTriopride ([¹⁸F]FTP) is a dopamine D₃-receptor preferring radioligand with potential for investigation of neuropsychiatric disorders including Parkinson disease, dystonia and schizophrenia. Here we estimate human radiation dosimetry for [¹⁸F]FTP based on the ex-vivo biodistribution in rodents and in vivo distribution in nonhuman primates. Biodistribution data were generated using male and female Sprague-Dawley rats injected with ~370 KBq of [¹⁸F]FTP and euthanized at 5, 30, 60, 120, and 240 min. Organs of interest were dissected, weighed and assayed for radioactivity content. PET imaging studies were performed in two male and one female macaque fascicularis administered 143-190 MBq of [¹⁸F]FTP

SUBMITTER: Laforest R 

PROVIDER: S-EPMC5218859 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature