TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis.

ABSTRACT:

Objectives

To identify important pathogen recognition receptor (PRR) pathways regulating innate immune responses and outcome in Staphylococcus aureus sepsis.

Methods

We analysed whether candidate PRR pathway genetic variants were associated with killed S. aureus-induced cytokine responses ex vivo and performed follow-up in vitro studies. We tested the association of our top-ranked variant with cytokine responses and clinical outcomes in a prospective multicentre cohort of patients with staphylococcal sepsis.

Results

An intronic TLR4 polymorphism and expression quantitative trait locus, rs1927907, was highly associated with cytokine release induced by stimulation of blood from healthy Thai subjects with S. aureus ex vivo. S. aureus did not induce TLR4-dependent NF-κB a

SUBMITTER: Chantratita N 

PROVIDER: S-EPMC5218870 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature