Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [¹¹C]DPA-713 positron emission tomography.

ABSTRACT: Objective Inflammation secondary to autoantibody-mediated effects occurring in multiple organs is a hallmark of systemic lupus erythematosus (SLE). The inflammatory response to SLE-mediated damage in brain parenchyma has been postulated in both normal and cognitively impaired individuals. Our goal is to use molecular imaging to investigate the distribution within the brain of the mitochondrial translocator protein (TSPO) that is upregulated during glial cell activation, and is considered as a marker of brain injury and repair. Methods We sought to characterize TSPO distribution in the brain of SLE patients using positron emission tomography (PET) and [¹¹C]DPA-713 (DPA), a radiopharmaceutical that targets TSPO. We imaged 11 healthy controls and 10 patients with SLE (years of diag

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5218990 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature