The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging.

ABSTRACT: Aging is tightly associated with redox events. The free radical theory of aging indicates that redox imbalance may be an important factor in the aging process. Most studies about redox and aging focused on the static status of oxidative stress levels, there has been little research investigating differential responses to redox challenge during aging. In this study, we used Caenorhabditis elegans and human fibroblasts as models to compare differential responses to oxidative stress challenge in young and old individuals. In response to paraquat stress, young individuals generated more ROS and activated signaling pathways including p-ERK, p-AKT and p-AMPKα/β. After the initial response, young individuals then promoted NRF2 translocation and induced additional antioxidant enzymes and higher ex

SUBMITTER: Meng J 

PROVIDER: S-EPMC5219648 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature